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Bio Reagents & Consumables
Cell Detection
Annexin V-AbFluor™ 555 Apoptosis Detection Kit (Orange Fluorescence)
Annexin V-AbFluor™ 555 Apoptosis Detection Kit allows the identification and quantification of apoptotic cells by flow cytometry or fluorescence microscopy.
Brand: Abbkine
Not Available
Free delivery within Singapore only
Specifications
| Applications notes | Abbkine Annexin V-AbFluor™ 555 Apoptosis Detection Kit contains Annexin V labeled with our proprietary orange fluorescent dye AbFluor™ 555, which allows the identification and quantification of apoptotic cells by flow cytometry or fluorescence microscopy. |
| Alternative | Annexin 5; Annexin V; AbFluor™ 555 |
Product Properties
| Kit components | • Annexin V Binding Buffer (5x) • Annexin V- AbFluor™ 555 |
| Features & Benefits | • Abbkine AbFluor™ 555 dye provides the same or better fluorescence and photostability as Alexa Fluor® 555, Cy™3, TRITC • Annexin V- AbFluor™ 555: Abs/Em = 555/565 nm • Suitable for flow cytometry or fluorescence microscopy |
| Storage instructions | Stable for at least 6 months at 4°C from date of shipment. Protect from light and do not freeze. |
| Shipping | Blue ice |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
Additional Information
| Background | Apoptosis is a form of programmed cell death to remove unwanted, damaged, or senescent cells from tissues. In normal cells, the negative phospholipids reside on the inner side of the cellular membrane while the outer surface of the membrane is occupied by uncharged phospholipids (PS). After a cell has entered apoptosis, the negatively charged PS are transported from the inner to the outer leaflet of the plasma membrane, thus exposing PS to the external cellular environment. The human anticoagulant, Annexin V, is a 35–36 kDa Ca2+-dependent phospholipid-binding protein that has a high affinity for PS. Annexin V labeled with a fluorophore or biotin can identify apoptotic cells by binding to PS exposed on the outer leaflet. |
| Alternative | Annexin 5; Annexin V; AbFluor™ 555 |
Compatible Products
| Brand | Catalog No. | Product Name |
| R&D Systems | 4830-250-K | TACS Annexin V-FITC Apoptosis Detection Kit |
Specification :
| Specifications | Kindly refer to the "Overview" tab. |
Integrin Beta3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways
Author: L Wei, Q Zhou, H Tian
Publication Name: International Journal of Biological Sciences
IF: 4.04
Integrin β3 is one of the main integrin heterodimer receptors on the surface of cardiac myocytes. Our previous studies showed that hypoxia induces apoptosis and increases integrin β3 expression in cardiomyocytes. However, the exact mechanism by which integrin β3 protects against apoptosis remains unclear. Hence, the present investigation aimed to explore the mechanism of integrin β3 in cardiomyocyte proliferation and hypoxia-induced cardiomyocyte apoptosis.