DS-11 Series Spectrophotometer / Fluorometer

Features

Award Winning Performance

DeNovix takes spectrophotometry to a whole new level of performance with the DS-11 Series. This easy-to-use, compact instrument delivers full spectrum UV-Vis analysis and fluorescence capability making it ideal for rapid nucleic acid and protein quantification. Our customers agree and have made the DeNovix DS-11 Series the twice winner of the Reviewers’ Choice Product of the Year and the first life science instrument to be awarded the Platinum Seal of Quality by SelectScience based on scientist reviews for outstanding ease-of-use, performance, service and technical support.

Best in Class 1 uL Sensitivity and Highest Absorbance Capability

DS-11 Series Spectrophotometers set the industry standard for the lower detection limits of 0.5 -1.0 uL UV-Vis sample analysis. Detect to 0.75 ng/uL dsDNA, 0.60 ng/uL RNA or 0.04 mg/mL BSA.  The DS-11 can measure samples with absorbance values as high as 750 absorbance units (at a 1 cm equivalent path length). This translates into 1125 mg/ml of BSA protein or 37500 ng/uL of dsDNA. This ultra high absorbance capability is achieved by using a remarkably small pathlength enabled by our SmartPath™ technology.

Easy to Learn. Fast to Use.

The DS-11 Series instruments feature the most powerful and intuitive software of its type. EasyApps™ software is designed by life scientists and combines with an intuitive touchscreen interface to ensure error-free operation and sample to data in under 3 seconds. Every instrument is ready to go right out of the box – no PC set-up or software installation required.

INTEGRATED ABSORBANCE AND FLUORESCENCE FOR UNMATCHED FLEXIBILITY

The Only All-In-One Microvolume and Cuvette Absorbance with Fluorescence Design

With the DS-11 Series you can equip your lab for today’s quantification requirements and for future assay challenges. Combine the ease of use, wide dynamic range and contamination information of UV-Vis with the enhanced sensitivity and specific quantification of fluorescence for total sample quality control.

Absorbance and Fluorescence quantification are unique but complementary methods for assessing concentration and quality of biological samples. The multi-award winning DS-11 Series of 1 µL Spectrophotometers and Fluorometers provides the most sensitive and widest dynamic range for UV-Vis absorbance and fluorescence capability in one combined instrument.

Sensitivity: Extend the lower detection limit for low concentration samples. Quantify down to 0.5 pg/µL dsDNA

Specificity: Selectively quantify your sample in the presence of contaminants using DeNovix Fluorescence Quantification Assays

Total Sample QC: Combine Absorbance and Fluorescence measurements for specific quantification and reliable contamination detection.

21 CFR Part 11 Compliance Ready

EasyApps Secure provides an optional suite of software controls that allow regulated GxP facilities to easily add DS-11 Series instruments to their compliant workflows. The software is fully integrated within the on-board operating system and includes a range of features essential to ensuring compliance, including:

• Password protected system access
• Integrated electronic signature controls
• Comprehensive user account management
• Secure audit trail recording
• Advanced data handling and export tools

Software Features

Nucleic Acid Quantification

• Separate preconfigured apps for optimized workflow
• Sample contaminant alerts
• Preconfigured and user defined factors for ssDNA ensures appropriate concentration calculations
• 260/280 and 260/230 ratios displayed
• 11 Preconfigured dyes and fluorophores for Microarray
• Option to add an unlimited number of new dyes for quick recall in Microarray

Protein Quantification

•   Preconfigured and user defined protein types for A280 and Labeled Proteins
•   Preconfigured Peptide app for easy peptide analysis at A205/215
•   Quick addition of new user defined protein types for improved workflow
•   Ultra short pathlength enables high absorbance capability: up to 750 mg/mL BSA
•   11 Preconfigured dyes and fluorophores for Labeled Proteins
•   Option to add an unlimited number of new dyes for quick recall in Labeled Proteins
•   BCA, Bradford, Lowry and 660 nm colorimetric assays optimized for ease of use
•   Quick save and recall of standard curves available

UV-Vis and Custom Apps

•   Simple but powerful apps enable measurement of more than just nucleic acids and proteins
•   Full spectrum analysis (190 – 840 nm)
•   Broad absorbance range for highly concentrated samples (up to 750 A, 1 cm equivalent)
•   Add new user-defined standard curve methods
•   Add custom formulas to eliminate downstream calculations
•   Add kinetics methods (DS-11+/DS-11FX+ models)

Fluorescence Quantification

• Four user-selectable LED light sources – compatible with all commonly used quantification assays e.g. DeNovix assays, Thermo Fisher Qubit™ assays, Thermo Fisher Quant-iT™ assays, and Promega Quantifluor™ assays
• Easy configuration of additional assays
• Single or multi-replicate standard curve options
• User control of line fit, trend line analysis, subtraction of blank
• User control of assay and reported sample concentration units
• Save and re-use curves and lists of standard concentrations

Custom Fluorescence Apps

• Add new standard curve based fluorescent assays (nucleic assay, protein or other)
• Basic Fluorometer app returns RFU values for a wide range of fluorophores

Kinetics and OD600

•   DS-11+ model enables cuvette-based kinetics studies
•   Full spectrum analysis (190 – 840 nm), with dual or single wavelength monitoring
•   Built-in heater with temperature control between 37° and 45° C.
•   Dual graphs enable absorbance vs time or absorbance vs. wavelength plots
•   All kinetic data saved
•   Estimated cell number calculator included in OD 600 app

User Accounts and Data Handling

•   Password protected accounts available
•   All data automatically saved & searchable by account, sample name & type, application and date
•   Configurable reports easily accommodate LIMS and user preferred formats
•   Print microfuge tube labels using a DeNovix supported printer
•   Print reports to a networked printer or DeNovix supported label printer
•   Export full data sets via email;  save to a network folder or USB thumb drive.

Exporting

Simply and securely connect the DS-11 to your network by Wi-Fi or Ethernet to enable data exporting by email, or print reports to network or label printers. Each measurement is automatically saved to a large onboard memory enabling storage and retrieval of millions of samples. For labs requiring external data storage, network folder locations can be defined for each user account to automatically export and archive results.

Multiple Model and Color Choices

The DS-11 Series is available in 4 models with different combinations of
microvolume absorbance (M), cuvette absorbance (C) and Fluorescence (F):

• DS-11 FX+ (M/C/F)
• DS-11 FX (M/F)
• DS-11+ (M/C)
• DS-11 (M)

All models are available in multiple colors (red, white, blue and silver)

Specifications

Spectrophotometer Microvolume Mode (DS-11, DS-11+, DS-11 FX, DS-11 FX+)

Spectrophotometer Cuvette Mode (DS-11+, DS-11 FX+)

Fluorometer Mode (DS-11 FX, DS-11 FX+ and FX Module)

Onboard Controller (No PC required)

General

FX Module: Upgrade to Fluorescence

Instantly add the power of fluorescence detection to any DeNovix DS-11, DS-11+ or DS-C Spectrophotometer. The FX Module uses the same fluorescence detection as the DS-11 FX, DS-11 FX+ and QFX. Simply plug in this USB powered accessory and DeNovix fluorometric EasyApps are immediately enabled. With four user-selectable LEDs, the easy-to-use apps are compatible with a wide range of commercially available assays including those designed for Thermo Fisher’s Qubit™ fluorometer and Promega’s Quantus™ fluorometer platforms.

Absorbance and Fluorescence Quantification Infographic

Absorbance and Fluorescence quantification are unique but complementary methods for assessing concentration and quality of biological samples. The multi-award winning DS-11 Series of 1 µL Spectrophotometers and Fluorometers provides the most sensitive and widest dynamic range for UV-Vis absorbance and fluorescence capability in one combined instrument.

Selecting the appropriate quantification methods for biological samples is an important consideration in any quality control process. Download our infographic featuring comparisons of the key features of absorbance and fluorescence quantification and information on when each method should be applied or the results combined.