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Material Science & Nanotechnology
Particle Size and Zeta Potential Analyzer
NanoBrook Omni Particle Size and Zeta Potential Analyzer with Microrheology
The NanoBrook Series is a Configurable Platform for Particle Sizing and Zeta Potential Measurements
The NanoBrook Series size and zeta potential analyzers incorporate all you need for fast, routine, sub-micron measurements of size and zeta potential. Based on the principles of Dynamic Light Scattering (DLS) for particle sizing and distribution, and based on doppler velocimetry (electrophoretic light scattering or ELS) for zeta potential measurement, most measurements only take a minute or two. The instrument also includes Phase Analysis Light Scattering (PALS) measurements for samples with low mobilities.
Rapid, Reliable, and Accurate Analysis
The NanoBrook Series particle size and zeta potential analyzers are based on the principles of Dynamic Light Scattering (DLS) for particle sizing and distribution, and based on doppler velocimetry (electrophoretic light scattering, ELS) for zeta potential measurement. Most measurements only take a minute or two. These instruments can also be configured with Phase Analysis Light Scattering (PALS) for samples with low mobilities or high conductivity measurements.
Three Possible Scattering Angles
Measurements of colloids are traditionally made using a 90° scattering angle. For smaller nanoparticles, proteins including IgG, mAbs, and peptides, these < 50 nm samples can be measured using the backscattering angle (173°). Finally the 15° detection angle can be selected for added sensitivity with aggregation measurements. Zeta potential measurements are always performed using the 15° detection angle to minimize diffusion broadening.
The NanoBrook Omni combines all of the most common configurations
With the NanoBrook Omni, measure samples in nearly every possible suspension environment from high salts such as PBS and sea water to organic solvents and aqueous solutions. Particle and protein sizing, with the highest sensitivity, utilize three measurement angles for truly unbiased measurement results.
Specifications
| Sample Type |
Sizing: Globular proteins, nanoparticles, and small polymers as well as most colloidal-sized materials in any non-absorbing liquid Zeta Potential: Proteins, nanoparticle, polymer and colloidal-sized materials, suspended in any non-absorbing liquid, with relative permittivity (dielectric constant) > 1.5 and viscosity < 30 cP. |
| Size Range |
Sizing: > 0.3 nm to 10 µm diameter, depending on refractive index and concentration Zeta potential: 1 nm to 100 µm, sample dependent |
| Mobility range | 10-11 to 10-7 m2 /V*s |
| Zeta potential range | -500 mV to 500 mV, sample dependent |
| Maximum sample conductivity |
Sizing: unlimited Zeta potential: 220 mS/cm, covering saline and PBS solutions for proteins, sample dependent |
| Sample Cells |
Sizing: 1 to 3 mL disposable plastic, 50 µL disposable, 40 µL quartz flow cell, 10 µL quartz minimum Zeta potential: 180 µL, 600 µL, 1250 µL |
| Concentration Range |
Sizing: 0.1 ppm to 50 mg/mL, depending on refractive index and concentration Zeta potential: 40% v/v, sample dependent |
| Signal Processing |
Sizing: Dynamic Light Scattering, DLS Zeta potential: Electrophoretic & true Phase Analysis Light Scattering, ELS & PALS |
| Correlator | Brookhaven's TurboCorr, multitau research grade with 510 hardware channels, covering the equivalent of 1010 linearly-spaced channels, 100% efficiency, real-time operation over the entire delay-time range |
| Precision |
Sizing: ± 1% typical Zeta Potential: ± 3% typical |
| Temperature Control | -5 °C to 110 °C, ± 0.1 °C, active control. No external circulator required. |
| Condensation Control | Purge facility using dry air, nitrogen preferred |
| Standard Laser | 40 mW red diode laser, nominal 640 nm wavelength |
| Scattering Angles | 15°, 90°, and 173° |
| Data Presentation |
Average & width, lognormal fit, and multimodal size distribution standard. Doppler Frequency Shift, electrophoretic mobility, zeta potential using Smoluchowski, Hückel or Henry. |
| Compliance | ISO 13321 and ISO 22412 compliant results |
| Power Requirements | 100/115/220/240 VAC, 50/60 Hz, 150 Watts |
| Dimensions | 23.3 x 42.7 x 48.1 (HWD in cm) |
| Weight | 15 kg |
| Environmental Characterisitics |
Temperature 10 °C to 75 °C |
| CE Certificate | Class I laser product, EN 60825-1:2001 CDRH |
Notes: * sample dependent
A policy of continual improvement may lead to specification changes.
| Specifications | Kindly refer to the "Overview" tab. |
