PhenoCode Signature Immuno-Contexture Human Protein Panel

Overview

Tumors characterized as "hot" exhibit signs of inflammation, high T cell infiltration, and expression of PD-L1. These inflamed tumors typically respond well to checkpoint inhibitor immunotherapy. PhenoCode Signature Immuno-Contexture panel (CD8, CD68, PD-L1, FoxP3, PanCK) enables profiling of the tumor microenvironment for CD8+ T lymphocytes and PD-L1 expression. Map additional phenotypes by adding a 6th marker to the panel from the antibody list below or add your own marker of interest by using the Antibody Conjugation Kit to barcode your antibody of choice.

Details

PhenoCode Signature panels are validated for the PhenoImager platform which integrates staining, imaging, and analysis using well-established workflows while providing accuracy and reproducibility. Featuring a flexible design component, PhenoCode Signature panels allow for the easy integration of a novel checkpoint or immune cell marker into a 5-plex base panel.

PhenoCode Signature Immuno-Contexture Human Protein Panel contains:

• 5 Primary antibodies targeting CD8, CD68, FoxP3, PD-L1, and Pan-Cytokeratin
• 5 PhenoCode Signature Detectors
• 5 Opal dyes + DMSO for signal amplification: Opal 480, Opal Opal 570, Opal 620, Opal 690, Opal 780 + TSA-DIG
• 10X Spectral DAPI
• 1X Plus Automation Amplification Diluent
• PhenoCode Signature Diluent
• 1X Antibody Diluent/Block
• PhenoCode Signature Blocker 1
• PhenoCode Signature Blocker 5
• N Blocker
• J Blocker
• S Blocker

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PhenoImager™ HT